Cord Serum Lipid Profile of Infants of Diabetic Mothers
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Abstract:
Background: Infants of diabetic mothers (IDM) is a critical issue in pediatrics, which is regarded as a major risk factor for birth trauma, respiratory distress syndrome (RDS), birth asphyxia, transient tachypnea of the newborn (TTN) and jaundice. IDM is also a risk factor for microvascular (e.g., ocular and renal complications) and macrovascular complications (e.g., cerebrovascular accident, atherosclerosis and cardiovascular complications). Lipids are a heterogeneous group of hydrophobic organic molecules which can be extracted from tissues using non-polar solvents. Lipids, due to their hydrophobic property, are mainly found in membranes enclosing various cell organelles. Diabetes mellitus management with insulin (nowadays also with oral hypoglycemic medications) has improved the outcomes of gestational diabetes mellitus (GDM) (most infants born to diabetic mother are large for gestational age). The neonatal mortality rate in IDM is over five times higher than that of infants of non-diabetic mothers. In this study, therefore, we aimed to assess the effect of maternal diabetes on cord serum lipid profile. Methods: This prospective (case-control) study was carried out on 60 infants born in Al-Zahra teaching hospital during February 2014–October 2014. The study group consisted of 30 randomly chosen IDM, and the control group comprised 30 infants who were born to healthy mothers. Results: The results of this study demonstrated that there are significant differences between IDM and infants of healthy mothers regarding lipid profile and birth weight. Conclusion: This study confirms that cord serum lipid profile (serum cholesterol, serum triglycerides and low-density lipoprotein) is higher at birth in IDM. Moreover, this study shows a significant association between lipid profile and body weight.
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cord serum lipid profile of infants of diabetic mothers
background: infants of diabetic mothers (idm) is a critical issue in pediatrics, which is regarded as a major risk factor for birth trauma, respiratory distress syndrome (rds), birth asphyxia, transient tachypnea of the newborn (ttn) and jaundice. idm is also a risk factor for microvascular (e.g., ocular and renal complications) and macrovascular complications (e.g., cerebrovascular accident, a...
full textCord Blood Serum Ferritin of Infants of Diabetic Mothers
Introduction:Maternal diabetes mellitus is associated with depleted fetal iron stores and this is proportionate to the degree of maternal control, presence or absence of diabetes-related complications, and is not related to maternal iron status. In this study, we aim to assess the effect of maternal diabetes on cord blood serum ferritin. Methods: The present prospective (case-control) study was...
full textcord blood serum ferritin of infants of diabetic mothers
introduction:maternal diabetes mellitus is associated with depleted fetal iron stores and this is proportionate to the degree of maternal control, presence or absence of diabetes-related complications, and is not related to maternal iron status. in this study, we aim to assess the effect of maternal diabetes on cord blood serum ferritin. methods: the present prospective (case-control) study was...
full textInfants of diabetic mothers.
9 Grodsky, G. M., and Forsham, P. H.: An immunochemical assay of total extractable insulin in man. J. Clin. Invest. 39:1070, i960. 10 Field, J. B., and Woodson, M. L.: Studies on the circulating insulin inhibitor found in some diabetic patients exhibiting chronic insulin resistance. J. Clin. Invest. 38:551, 1959. 11 Mitchell, M. L.: Interaction of radioinsulin with serum proteins in vitro and w...
full textInfants of diabetic mothers.
Advances in the management of the mother with diabetes have reduced the rate of morbidity and mortality for her infant. Aggressive control of maternal glycemic status is warranted, because most morbidities are epidemiologically and pathophysiologically closely linked to fetal hyperglycemia and hyperinsulinemia. The burgeoning public health problem of overweight and obesity in children will like...
full textInfants of diabetic mothers.
Infants of diabetic mothers (IDMs) can present with various symptoms and disorders. The neonatal nurse must be able to assess the infant for glucose control and other anomalies.
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volume 6 issue 4
pages 7- 14
publication date 2015-12-01
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